Referenties:
1. Papas, A.M., Diet and antioxidant status, in Antioxidant Status, Diet, Nutrition, and Health, Papas, A.M., Ed., CRC Press, Boca Raton, Florida, 1998, chap. 5.
2. Chesson, A. and Collins, A., Assessment of the role of diet in cancer prevention, Cancer Lett., 114, 237, 1997.
3. Lee, B.M. and Park, K.-K., Beneficial and adverse effects of chemopreventive agents, Mutat. Res., 523-524, 265, 2003.
4. Sporn, M.B. and Suh, N., Chemoprevention: an essential approach to controlling cancer, Nature Rev. Cancer, 2, 537, 2002.
5. Wargovich, M.J., Experimental evidence for cancer preventive elements in food, Cancer Lett., 114, 11, 1997.
6. Potter, J.D., Cancer prevention: epidemiology and experiment, Cancer Lett., 114, 7, 1997.
7. Eastwood, M.A., Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease?, Q. J. Med., 92, 527, 1999.
8. Zhang, S. et al., Dietary carotenoids and vitamins A, C, and E and risk of breast cancer, J. Natl. Cancer Inst., 91, 547, 1999.
9. Holick, C.N. et al., Dietary carotenoids, serum β-carotene, and retinol and risk of lung cancer in the Alpha-Tocopherol, Beta-Carotene cohort study, Am. J. Epidemiol., 156, 536, 2002.
10. Rock, C.L., Carotenoid update, J. Am. Diet. Assoc., 103, 423, 2003. 26
11. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, N. Engl. J. Med., 330, 1029, 1994.
12. Hennekens, C.H. et al., Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease, N. Engl. J. Med., 334, 1145, 1996.
13. Omenn, G.S. et al., Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease, N. Engl. J. Med., 334, 1150, 1996.
14. Murakoshi, M. et al., Potent preventive action of α-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed
more effectively by α-carotene than by β-carotene, Cancer Res., 52, 6583, 1992.
15. Levy, J. et al., Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene, Nutr. Cancer 24, 257, 1995.
16. Park, J.S., Chew, B.P., and Wong, T.S., Dietary lutein from marigold extract inhibits mammary tumor development in BALB/c mice, J. Nutr., 128, 1650, 1998.
17. Chew, B.P. et al., A comparison of the anticancer activities of dietary β-carotene, canthaxanthin and astaxanthin in mice in vivo, Anticancer Res., 19, 1849, 1999.
18. Maher, T.J., Astaxanthin continuing education module, New Hope Institute of Retailing, Boulder, Colorado, 2000.
19. Naguib, Y., Pioneering astaxanthin, Nutr. Sci. News, 6, 58, 2001. 27
20. Guerin, M., Huntley, M.E., and Olaizola, M., Haematococcus astaxanthin: applications for human health and nutrition, Trends Biotechnol., 21, 210, 2003.
21. Davies, K.J.A., Oxidative stress: the paradox of aerobic life, Biochem. Soc. Symp., 61, 1, 1995.
22. Ames, B.N., Shigenaga, M.K., and Hagen, T.M., Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. USA, 90, 7915, 1993.
23. Ames, B.N. and Shigenaga, M.K., Oxidants are a major contributor to aging, Ann. NY Acad. Sci., 663, 85, 1992.
24. Block, G., Patterson, B., and Subar, A., Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence, Nutr. Cancer, 18, 1, 1992.
25. Steinmetz, K.A. and Potter, J.D., Vegetables, fruit, and cancer prevention: a review, J. Am. Diet. Assoc., 96, 1027, 1996.
26. Giovannucci, E., Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiological literature, J. Natl. Cancer Inst., 91, 317, 1999.
27. Krinsky, N.I., The antioxidant and biological properties of the carotenoids, Ann. NY Acad. Sci., 854, 443, 1998.
28. Krinsky, N.I., Carotenoids in medicine, in Carotenoids: Chemistry and Biology, Krinsky, N.I., Ed., Plenum Press, New York, 1990, 279.
29. Wolf, G., Retinoids and carotenoids as inhibitors of carcinogenesis and inducers of cell-cell communication, Nutr. Rev., 50, 270, 1992.
30. Schiedt, K., New aspects of carotenoid metabolism in animals, in Carotenoids:
31. Peto, R., Doll, R., Buckley, J.D., and Sporn, M.B., Can dietary beta-carotene materially reduce human cancer rates?, Nature, 290, 201, 1981.
32. Bland, J., The beta-carotene controversy in perspective, J. Appl. Nutr., 48, 42, 1996.
33. Khachik, F., Askin, F.B., and Lai, K., Distribution, bioavailability, and metabolism of carotenoids in humans, in Phytochemicals: A New Paradigm, Bidlack, W.R. et al., Eds., Technomic Publishing Company, Lancaster, Pennsylvania, 1998, chap. 5.
34. Khachik, F., Beecher, G.R., and Smith, J.C., Jr., Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer, J. Cell. Biochem. Suppl., 22, 236, 1995.
35. King, T.J. et al., Metabolites of dietary carotenoids as potential cancer preventive agents, Pure & Appl. Chem., 69, 2135, 1997.
36. Palozza, P. and Krinsky, N.I., β-carotene and α-tocopherol are synergistic antioxidants, Arch. Biochem. Biophys., 297, 184, 1992.
37. Bˆhm, F., et al., Carotenoids enhance vitamin E antioxidant efficiency, J. Am. Chem. Soc., 119, 621, 1997.
38. Chen, H. and Tappel, A.L., Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to liver slices measured by oxidized heme proteins, Free Rad. Biol. & Med., 16, 437, 1994.
39. Stahl, W. et al., Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein, FEBS Lett., 427, 305, 1998.
40. Young, A.J. and Lowe, G.M., Antioxidant and prooxidant properties of carotenoids, Arch. Biochem. Biophys., 385, 20, 2001.
41. Paolini, M. et al., β-carotene: a cancer chemopreventive agent or a co-carcinogen?, Mutat. Res., 543, 195, 2003.
42. Burton, G.W. and Ingold, K.U., β-carotene: an unusual type of lipid antioxidant, Science, 224, 569, 1984.
43. Zhang, P. and Omaye, S.T., β-carotene and protein oxidation: effects of ascorbic acid and α-tocopherol, Toxicology, 146, 37, 2000.
44. Crabtree, D.V. and Adler, A.J., Is β-carotene an antioxidant?, Med. Hypoth., 48, 183, 1997.
45. Zhang, P. and Omaye, S.T., Antioxidant and prooxidant roles for β-carotene, α-tocopherol and ascorbic acid in human lung cells, Toxicol. in Vitro, 15, 13, 2001.
46. Khachik, F. et al., Separation and identification of carotenoids and their oxidation products in the extracts of human plasma, Anal. Chem., 64, 2111, 1992.
47. Bernhard, K., Synthetic astaxanthin: the route of a carotenoid from research to commercialisation, in Carotenoids: Chemistry and Biology, Krinsky, N.I., Ed., Plenum Press, New York, 1990, 337.
48. Lorenz, R.T. and G.R. Cysewski, Commercial potential for Haematococcus microalgae as a natural source of astaxanthin, Trends Biotechnol., 18, 160, 2000.
49. Landrum, J.T., Bone, R.A., and Herrero, C., Astaxanthin, β-cryptoxanthin, lutein, and zeaxanthin, in Phytochemicals in Nutrition and Health, Meskin, M.S. et al., Eds., CRC
Press, Boca Raton, Florida, 2002, chap. 12.
50. Baker, R.T.M., Canthaxanthin in aquafeed applications: is there any risk?, Trends Food Sci. & Technol., 12, 240, 2002.
51. Astorg, P., Food carotenoids and cancer prevention: an overview of current research, Trends Food Sci. & Technol., 8, 406, 1997.
52. Nishino, H., Cancer prevention by carotenoids, Mutat. Res., 402, 159, 1998.
53. Nishino, H. et al., Carotenoids in cancer chemoprevention, Cancer Metastasis Rev., 21, 257, 2002.
54. Nguyen, M.L., and Schwartz, S.J., Lycopene: chemical and biological properties, Food Technol., 53, 38, 1999.
55. Di Mascio, P., Kaiser, S., and Sies, H., Lycopene as the most efficient biological carotenoid singlet oxygen quencher, Arch. Biochem. Biophys., 274, 532, 1989.
56. Stahl, W. and Sies, H., Lycopene: a biologically important carotenoid for humans?, Arch. Biochem. Biophys., 336, 1, 1996.
57. Gerster, H., The potential role of lycopene for human health, J. Am. Coll. Nutr., 16, 109, 1997.
58. Clinton, S.K. et al., cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, Cancer Epidemiol. Biomarkers Prev., 5, 823, 1996.
59. Giovannucci, E. et al., Intake of carotenoids and retinol in relation to risk of prostate cancer, J. Natl. Cancer Inst., 87, 1767, 1995.
60. Clinton, S.K., Lycopene: chemistry, biology, and implications for human health and 31 disease, Nutr. Rev., 56, 35, 1998.
61. Landrum, J.T. et al., A one year study of the macular pigment: the effect of 140 days of a lutein supplement, Exp. Eye Res., 65, 57, 1997.
62. Sommerburg, O.G. et al., Lutein and zeaxanthin are associated with photoreceptors in the human retina, Curr. Eye Res., 19, 491, 1999.
63. Landrum, J.T. and Bone, R.A., Lutein, zeaxanthin, and the macular pigment, Arch. Biochem. Biophys., 385, 28, 2001.
64. Le Marchand, L. et al., An ecological study of diet and lung cancer in the South Pacific, Int. J. Cancer, 63, 18, 1995.
65. Voorrips, L.E. et al., A prospective cohort study on antioxidant and folate intake and male lung cancer risk, Cancer Epidemiol. Biomarkers Prev., 9, 357, 2000.
66. de MejÌa, E.G., Loarca-PiÒa, G., and Ramos-GÛmez, M., Antimutagenicity of xanthophylls present in Aztec Marigold (Tagetes erecta) against 1-nitropyrene, Mutat. Res., 389, 219, 1997.
67. Narisawa, T. et al., Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats, Cancer Lett., 107,
137, 1996.
68. Nishino, H. et al., Cancer prevention by carotenoids and curcumins, in Phytochemicals as Bioactive Agents, Bidlack, W.R. et al., Eds., Technomic Publishing Company, Lancaster, Pennsylvania, 2000, chap. 9.
69. Brown, C.M. et al., Dietary lutein inhibits mouse mammary tumor growth by xanthophylls, astaxanthin and canthaxanthin, Cancer Res., 55, 4059, 1995.
79. Zhang, L.-X., Cooney, R.V., and Bertram, J.S., Carotenoids up-regulate Connexin43 gene expression independent of their provitamin A or antioxidant properties, Cancer Res., 52, 5707, 1992.
80. Hanusch, M. et al., Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin, Arch. Biochem. Biophys., 317, 423, 1995.
81. Gradelet, S. et al., Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat, Xenobiotica, 26, 49, 1996.
82. Jewell, C. and OíBrien, N.M., Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat, Brit. J. Nutr., 81, 235, 1999.
83. Goralczyk, R. et al., Occurrence of birefringent retinal inclusions in cynomolgus monkeys after high doses of canthaxanthin, Invest. Ophthalmol. & Vis. Sci., 38, 741, 1997.
84. Leyon, H. et al., Reversibility of canthaxanthin deposits within the retina, Acta Ophthalmol., 68, 607, 1990.
85. Kotake-Nara, E. et al., Carotenoids affect proliferation of human prostate cancer cells, J. Nutr., 131, 3303, 2001.
86. Dore, J.E. and G.R. Cysewski, Haematococcus algae meal: a source of natural astaxanthin for aqua feeds, Aqua Feed Int., 6, 22, 2003.
87. Di Mascio, P. et al., Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers, Biochem. Soc. Trans., 18, 1054, 1990.
88. Shimidzu, N., Goto, M., and Miki, W., Carotenoids as singlet oxygen quenchers in marine organisms, Fish. Sci., 62, 134, 1996.
89. Miki, W., Biological functions and activities of animal carotenoids, Pure & Appl. Chem., 63, 141, 1991.
90. Terao, J., Antioxidant activity of β-carotene-related carotenoids in solution, Lipids, 24, 659, 1989.
91. Woodall, A.A., Britton, G., and Jackson, M.J., Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability,
Biochim. Biophys. Acta, 1336, 575, 1997.
92. Haila, K.M. et al., Carotenoid reaction with free radicals in acetone and toluene at different oxygen partial pressures: an ESR spin-trapping study of structure-activity relationships, Z. Lebensm. Unters Forsch. A, 204, 81, 1997.
93. Naguib, Y.M.A., Antioxidant activities of astaxanthin and related carotenoids, J. Agric. Food Chem., 48, 1150, 2000.
94. Bagchi, D., Oxygen free radical scavenging abilities of vitamins C, E, β-carotene, pycnogenol, grape seed proanthocyanidin extract, astaxanthin and BioAstinÆin vitro, Final Report to Cyanotech Corporation, Creighton University School of Health Sciences, Omaha, Nebraska, 2001.
95. Lim, B.P. et al., Antioxidant activity of xanthophylls on peroxyl radical-mediated 35 phospholipid peroxidation, Biochim. Biophys. Acta, 1126, 178, 1992.
96. Palozza, P. and N.I. Krinsky, Astaxanthin and canthaxanthin are potent antioxidants in a membrane model, Arch. Biochem. Biophys., 297, 291, 1992.
97. Nishigaki, I. et al., Suppressive effect of astaxanthin on lipid peroxidation induced in rats, J. Clin. Biochem. Nutr., 16, 161, 1994.
98. Nakagawa, K. et al., Inhibition by β-carotene and astaxanthin of NADPH-dependent microsomal phospholipid peroxidation, J. Nutr. Sci. Vitaminol., 43, 345, 1997.
99. Rengel, D. et al., Exogenously incorporated ketocarotenoids in large unilamellar vesicles: protective activity against peroxidation, Biochim. Biophys. Acta, 1463, 179, 2000.
100. Cantrell, A. et al., Singlet oxygen quenching by dietary carotenoids in a model membrane environment, Arch. Biochem. Biophys., 412, 47, 2003.
101. Oshima, S. et al., Inhibitory effect of β-carotene and astaxanthin on photosensitized oxidation of phospholipid bilayers, J. Nutr. Sci. Vitaminol., 39, 607, 1993.
102. OíConnor, I. And OíBrien, N., Modulation of UVA light-induced oxidative stress by β-carotene, lutein and astaxanthin in cultured fibroblasts, J. Dermatol. Sci., 16, 226, 1998.
103. Lawlor, S.M. and OíBrien, N.M., Astaxanthin: antioxidant effects in chicken embryo fibroblasts, Nutr. Res., 15, 1695, 1995.
104. Tinkler, J.H. et al., Dietary carotenoids protect human cells from damage, J. Photochem. Photobiol. B: Biol., 26, 283, 1994.
105. Iwamoto, T. et al., Inhibition of low-density lipoprotein oxidation by astaxanthin, J. Atheroscler. Thromb., 7, 216, 2000.
106. Hagen, C., Braune, W., and Greulich, F., Functional aspects of secondary carotenoids in Haematococcus lacustris [Girod] Rostafinski (Volvocales) IV. Protection from photodynamic damage, J. Photochem. Photobiol. B: Biol., 20, 53, 1993.
107. Nakano, T. et al., Effect of astaxanthin rich red yeast (Phaffia rhodozyma) on oxidative stress in rainbow trout, Biochim. Biophys. Acta, 1426, 119, 1999.
108. Bell, J.G. et al., Depletion of α-tocopherol and astaxanthin in Atlantic salmon (Salmo salar) affects autooxidative defense and fatty acid metabolism, J. Nutr., 130, 1800, 2000.
109. Kurashige, M. et al., Inhibition of oxidative injury of biological membranes by astaxanthin, Physiol. Chem. Phys. & Med. NMR, 22, 27, 1990.
110. Kang, J.O., Kim, S.J., and Kim, H., Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats, Meth. Find. Exp. Clin. Pharmacol., 23, 79, 2001.
111. Di Mascio, P., Murphy, M.E., and Sies, H., Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols, Am. J. Clin. Nutr., 53, 194S, 1991.
112. Mortensen, A. and Skibsted, L.H., Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. A real time kinetic study of antioxidant hierarchy, FEBS Lett., 417, 261, 1997.
113. Mortensen, A. et al., Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants, FEBS Lett., 418, 91, 1997
114. Miller, N.J. et al., Antioxidant activities of carotenes and xanthophylls, FEBS Lett., 384, 240, 1996.
115. Mortensen, A., Skibsted, L.H., and Truscott, T.G., The interaction of dietary carotenoids with radical species, Arch. Biochem. Biophys., 385, 13, 2001.
116. Burke, M. et al., One-electron reduction potentials of dietary carotenoid radical cations in aqueous micellar environments, FEBS Lett., 500, 132, 2001.
117. Edge, R. et al., Relative one-electron reduction potentials of carotenoid radical cations and the interactions of carotenoids with the vitamin E radical cation, J. Am. Chem. Soc., 120, 4087, 1998.
118. Fukuzawa, K. et al., Rate constants for quenching singlet oxygen and activities for inhibiting lipid peroxidation of carotenoids and α-tocopherol in liposomes, Lipids, 33, 751, 1998.
119. Barros, M.P. et al., Astaxanthin and peridinin inhibit oxidative damage in Fe2+-loaded liposomes: scavenging oxyradicals or changing membrane permeability?, Biochem. Biophys. Res. Comm., 288, 225, 2001.
120. Socaciu, C. et al., Different ways to insert carotenoids into liposomes affect structure and dynamics of the bilayer differently, Biophys. Chem., 99, 1, 2002.
121. Gabrielska, J. and Gruszecki, W.I., Zeaxanthin (dihydroxy-β-carotene) but not β-carotene rigidifies lipid membranes: a 1H-NMR study of carotenoid-egg phosphatidylcholine liposomes, Biochim. Biophys. Acta, 1285, 167, 1996.
122. Sujak, A. et al., Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects, Arch. Biochem. Biophys., 371, 301, 1999.
123. Goto, S. et al., Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin, Biochim. Biophys. Acta, 1512, 251, 2001.
124. J ̄rgensen, K. and Skibsted, L.H., Carotenoid scavenging of radicals: effect of carotenoid structure and oxygen partial pressure on antioxidative activity, Z. Lebensm. Unters Forsch., 196, 423, 1993.
125. Martin, H.-D. et al., Anti- and prooxidant properties of carotenoids, J. Prakt. Chem., 341, 302, 1999.
126. Beutner, S. et al., Quantitative assessment of antioxidant properties of natural colorants and phytochemicals: carotenoids, flavonoids, phenols and indigoids. The role of β-carotene in antioxidant functions, J. Sci. Food Agric.
, 81, 559, 2001.
127. Anonymous, Eskimo diets and diseases, Lancet, 1(8334), 1139, 1983.
128. Bates, C. et al., Plasma essential fatty acids in pure and mixed race American Indians on and off a diet exceptionally rich in salmon, Prostaglandins Leukot. Med., 17, 77, 1985.
129. Sun, S. et al., Anti-tumor activity of astaxanthin on Meth-A tumor cells and its mode of action, FASEB J., 12, A966, 1998.
130. Kim, H.W., Park, J.S., and Chew, B.P., β-carotene and astaxanthin inhibit mammary tumor cell growth and induce apoptosis in mice in vitro, FASEB J., 15, A298, 2001.
131. Kozuki, Y., Miura, Y., and Yagasaki, K., Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture, Cancer Lett., 151, 111, 2000.
132. Levy, J. et al., Lycopene and astaxanthin inhibit human prostate cancer cell proliferation induced by androgens, presented at 13th Int. Carotenoid Symp., Honolulu, January 6-11, 2002, 135.
133. Lyons, N.M. and OíBrien, N.M., Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture, J. Dermatol. Sci., 30, 73, 2002.
134. Jyonouchi, H. et al., Antitumor activity of astaxanthin and its mode of action, Nutr. Cancer, 36, 59, 2000.
135. Lee, S.H. et al., Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by astaxanthin containing egg yolks, Agric. Chem. Biotechnol., 40, 490, 1997.
136. Lee, S.H. et al., Inhibition of sarcoma-180 cell-induced mouse ascites cancer by astaxanthin-containing egg yolks, J. Kor. Soc. Food Sci. Nutr., 27, 163, 1998.
137. SavourÈ, N. et al., Vitamin A status and metabolism of cutaneous polyamines in the hairless mouse after UV irradiation: action of β-carotene and astaxanthin, Int. J. Vit. Nutr. Res., 65, 79, 1995.
138. Mori, H. et al., Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis, J. Cell. Biochem. Suppl., 27, 35, 1997.
139. Tanaka, T. et al., Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin, Carcinogenesis, 15, 15, 1994.
140. Gradelet, S. et al., Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers, Cancer Lett., 114, 221, 1997.
141. Gradelet, S. et al., Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism, Carcinogenesis, 19, 403, 1998.
142. Yang, Z. et al., Protective effect of astaxanthin on the promotion of cancer metastases in mice treated with restraint-stress, J. Jpn. Soc. Nutr. Food Sci., 50, 423, 1997.
143. Kurihara, H. et al., Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress, Life Sci., 70, 2509, 2002.
144. Astorg, P. et al., Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat, Nutr. Cancer, 29, 60, 1997.
145. Park, J.S. et al., Dietary lutein but not astaxanthin or β-carotene increases pim-1 gene expression in murine lymphocytes, Nutr. Cancer, 33, 206, 1999.
146. Black, H.S., Radical interception by carotenoids and effects on UV carcinogenesis, Nutr. Cancer, 31, 212, 1998.
147. Rousseau, E.J., Davison, A.J., and Dunn, B., Protection by β-carotene and related compounds against oxygen-mediated cytotoxicity and genotoxicity: implications for carcinogenesis and anticarcinogenesis, Free Radical Biol. & Med.
, 13, 407, 1992.
148. Aoi, W. et al., Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice, Antioxid. Redox Signal., 5, 139, 2003.
149. Uchiyama, K. et al., Beneficial effects of astaxanthin in type 2 diabetes model of db/db mouse, Free Radical Biol. & Med., 33, S211, 2002.
150. Uchiyama, K. et al., Astaxanthin protects beta-cells against glucose toxicity in diabetic db/db mice, Redox Rep., 7, 290, 2002.
151. Tso, M.O.M. and Lam, T.-T., Method of retarding and ameliorating central nervous system and eye damage, United States Patent 5,527,533, 1996.
152. Wu, T.-H., Shah, P., and Maher, T.J., An astaxanthin-containing algal extract attenuates selenite-induced nuclear cataract formation in rat pups, FASEB J., 16, A958, 2002.
153. Okada, F., Inflammation and free radicals in tumor development and progression, Redox Rep., 7, 357, 2002.
154. Wang, X., WillÈn, R., and Wadstrˆm, T., Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice, Antimicrob. Agents Chemotherapy, 44, 2452, 2000.
155. Bennedsen, M. et al., Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes, Immunol. Lett., 70, 185, 1999.
156. Liu, B.H. and Lee, Y.K., Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori-infected BALB/c mice, Int. Immunopharmacol., 3, 979, 2003.
157. Ohgami, K. et al., Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo, Invest. Ophthalmol. Vis. Sci., 44, 2694, 2003.
158. Nir, Y., Spiller, G., and Multz, C., Effect of an astaxanthin containing product on rheumatoid arthritis, J. Am. Coll. Nutr., 21, 490, 2002.
159. Nir, Y., Spiller, G., and Multz, C., Effect of an astaxanthin containing product on carpal tunnel syndrome, J. Am. Coll. Nutr., 21, 489, 2002.
160. Bendich, A., Carotenoids and the immune response, J. Nutr., 119, 112, 1989.
161. Bendich, A., Carotenoids and the immune system, in Carotenoids: Chemistry and Biology, Krinsky, N.I., Ed., Plenum Press, New York, 1990, 323.
162. Okai, Y., and Higashi-Okai, K., Possible immunomodulating activities of carotenoids in in vitro cell culture experiments, Int. J. Immunopharmacol., 18, 753, 1996.
163. Jyonouchi, H. et al., Studies of immunomodulating actions of carotenoids. I. Effects of β-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system, Nutr. Cancer
, 16, 93, 1991.
164. Jyonouchi, H., Zhang, L., and Tomita, Y., Studies of immunomodulating actions of carotenoids. II. Astaxanthin enhances in vitro antibody production to T-dependent antigens without facilitating polyclonal B-cell activation, Nutr. Cancer, 19, 269, 1993.
165. Jyonouchi, H. et al., Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens, Nutr. Cancer, 21, 47, 1994.
166. Jyonouchi, H. et al., Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of 43 antigen, J. Nutr., 125, 2483, 1995.
167. Jyonouchi, H. et al., Effects of various carotenoids on cloned, effector-stage T-helper cell activity, Nutr. Cancer, 26, 313, 1996.
168. Jyonouchi, H., Sun, S., and Gross, M., Effect of carotenoids on in vitroimmunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro
immunoglobulin production in response to a T-dependent stimulant and antigen, Nutr. Cancer, 23, 171, 1995.
169. Chew, B.P. et al., Dietary β-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice, Anticancer Res., 19, 5223, 1999.
170. Tomita, Y. et al., Preventive action of carotenoids on the development of lymphadenopathy and proteinuria in MRL-lpr/lpr mice, Autoimmunity, 16, 95, 1993.
171. Bertram, J.S., Carotenoids and gene regulation, Nutr. Rev., 57, 182, 1999.
172. Zhang, L.X., Cooney, R.V., and Bertram, J.S., Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action, Carcinogenesis, 12, 2109, 1991.
173. Banoub, R.W., Fernstrom, M., and Ruch, R.J., Lack of growth inhibition or enhancement of gap junctional intercellular communication and connexin 43 expression by β-carotene in murine lung epithelial cells in vitro, Cancer Lett., 108, 35, 1996.
174. Gradelet, S. et al., β-apo-8í-carotenal, but not β-carotene, is a strong inducer of liver 44 cytochromes P4501A1 and 1A2 in rat, Xenobiotica, 26, 909, 1996.
175. Astorg, P. et al., Effects of provitamin A or non-provitamin A carotenoids on liver xenobiotic-metabolizing enzymes in mice, Nutr. Cancer, 27, 245, 1997.
176. Kistler, A. et al., Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes, Arch. Toxicol., 75, 665, 2002.
177. Rauscher, R., Edenharder, R., and Platt, K.L., In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids, Mutat. Res., 413, 129, 1998.
178. Anderson, M., Method of inhibiting 5α-reductase with astaxanthin, United States Patent 6,277,417, 2001.
179. Murakami, C. et al., Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases, Biochim. Biophys. Acta, 1574, 85, 2002.
180. Dore, J.E., Safety profile: BioAstinÆ natural astaxanthin, Technical Bulletin Ax-072, Cyanotech Corporation, Kailua-Kona, Hawaii, 2002.
181. Ono, A. et al., A 13-week subchronic oral toxicity study of Haematococcus color in F344 rats, Bull. Natl. Health Sci., 117, 91, 1999.
182. Spiller, G.A. and Dewell, A., Safety of an astaxanthin-rich Haematococcus pluvialisalgal extract: a randomized clinical trial, J. Med. Food, 6, 51, 2003.
183. Furr, H.C. and Clark, R.M., Intestinal absorption and tissue distribution of carotenoids, J. Nutr. Biochem., 8, 364, 1997.
184. Zaripheh, S. and Erdman, J.W., Factors that influence the bioavailability of xanthophylls, J. Nutr., 132, 531S, 2002.
185. Castenmiller, J.J. et al., The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans, J. Nutr., 129, 349, 1999.
186. Lavy, A., Ben Amotz, A., and Aviram, M., Preferential inhibition of LDL oxidation by the all-trans isomer of β-carotene in comparison with 9-cisβ-carotene, Eur. J. Clin. Chem. Clin. Biochem., 31, 83, 1993.
187. Gartner, C., Stahl, W., and Sies, H., Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human, Int. J. Vitam. Nutr. Res., 66, 119, 1996.
188. Brown, E.D. et al., Vegetable concentrates interact with canthaxanthin to affect carotenoid bioavailability and superoxide dismutase activity but not immune response in rats, Nutr. Res., 17, 989, 1997.
189. Roodenburg, A.J. et al., Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans, Am. J. Clin. Nutr., 71, 1187, 2000.
190. Clark, R.M. and Furr, H.C., Absorption of canthaxanthin by the rat is influenced by total lipid in the intestinal lumen, Lipids, 36, 473, 2001.
191. Clark, R.M. et al., A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions, Lipids, 35, 803, 2000. 46
192. Schiedt, K., Absorption and metabolism of carotenoids in birds, fish and crustaceans, in Carotenoids, vol. 3: Biosynthesis and Metabolism, Britton, G., Liaaen-Jensen, S., and Pfander, H., Eds., Birkhauser, Basel, 1998, 285.
193. Wolz, E. et al., Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes, Drug Metab. Dispos., 27, 456, 1999.
194. ÿsterlie, M, Bjerkeng, B., and Liaaen-Jensen, S., Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin, J. Nutr. Biochem., 11, 482, 2000.
195. Elmadfa, I. And Majchrzak, D., Absorption and transport of astaxanthin and canthaxanthin in humans after a salmon meal, Ern‰hrungs-Umschau, 46, 173, 1999.
196. Odeberg, J.M. et al., Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations, Eur. J. Pharm. Sci., 19, 299, 2003.
197. Wright, M.E. et al., Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri womenís health study (United States), Cancer Causes Control, 14, 85, 2003.
198. Goodman, G.E. et al., The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial, Cancer Epidemiol. Biomarkers Prev., 12, 518, 2003.
199. Le Marchand, L. et al., Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii, J. Natl. Cancer Inst., 81, 1158, 1989.
200. Russell, R.M., Lycopene and lutein: the next steps to the mixed carotenoids, in Nutraceuticals in Health and Disease Prevention, Kr‰mer, K., Hoppe, P.-P., and Packer, L., Eds., Marcel Dekker, New York, 2001, chap. 6.